Arthrochalasia Type (Formerly EDS Type VII A&B)

Congenital hip dislocation has been present in all biochemically proven individuals with this type of EDS. Individuals often have severe generalized joint hypermobility with recurrent subluxations. Other manifestations of this type may include: skin hyperextensibility with easy bruising; tissue fragility including atrophic scars; muscle hypotonia; kyphoscoliosis; and radiologically mild osteopenia.

The Arthrochalasia Type is caused by mutations leading to deficient processing of the amino-terminal end of proa1(I) [type A] or proa2(I)[type B] chains of collagen type I. It is inherited in an autosomal dominant manner. A skin biopsy can also diagnose this type of EDS.