Petra Klinge, MD

Petra Klinge, MD is an internationally renowned general neurosurgeon specializing in the surgical treatment of patients with, hydrocephalus, pediatric diseases and treatment of congenital diseases like Chiari malformation, tethered cord and spinal malformations.

Dr. Klinge is a professor of neurosurgery at The Warren Alpert School of Medicine at Brown University. Prior to this, she was professor of neurosurgery at the Medical School Hannover, Germany. She received her medical degree at the University of Kiel in 1993 and completed her neurosurgical residency at Hannover Medical School in Germany in 2002. She was senior associate professor of neurosurgery at the International Neuroscience Institute in Hannover, Germany, where she had the opportunity to be educated by Professor M. Samii, a founder of modern skull base and spine surgery.

Dr. Klinge is an active member of the American Association of Neurosurgeons and the Congress of Neurological Surgeons. She is editor in chief of the Elsevier journal Interdisciplinary Neurosurgery: Advanced Techniques and Case Management (INAT) and associate editor of Clinical Neurology and Neurosurgery (CNN). She also serves as reviewer for international scientific journals including Neurosurgery, Journal of Neurosurgery, Journalof Neurology, Neurosurgery & Psychiatry and others. She is past president of the International Society for Hydrocephalus and CSF disorders.

Dr. Klinge’s scientific interests and recent publications focus on the development of advanced pathophysiological understanding, diagnosis and surgical treatment of tethered cord syndrome and Chiari pathologies in EDS and rare genetic syndromes, including Myodural bridges pathology.  She is also working on the implications of ADULT-ONSET tethered cord syndrome and the life-long implications of tethered cord.

Her scientific publications are listed by the US National Library of Medicine.

Professional Papers
1: Henderson FC Sr, Austin C, Benzel E, Bolognese P, Ellenbogen R, FrancomanoCA, Ireton C, Klinge P, Koby M, Long D, Patel S, Singman EL, Voermans NC. Neurological and spinal manifestations of the Ehlers-Danlos syndromes. Am J MedGenet C Semin Med Genet. 2017 Mar;175(1):195-211. doi: 10.1002/ajmg.c.31549. Epub 2017 Feb 21. PMID: 28220607.

2: Doberstein CA, Torabi R, Klinge PM. Current Concepts in the Pathogenesis, Diagnosis, and Management of Type I Chiari Malformations. R I Med J (2013). 2017 Jun 1;100(6):47-49. PMID: 28564670.

3: Brinker T, Stopa E, Morrison J, Klinge P. A new look at cerebrospinal fluid circulation. Fluids Barriers CNS. 2014 May 1;11:10. doi: 10.1186/2045-8118-11-10. PMID: 24817998; PMCID: PMC4016637.

4: Rossetti MA, Piryatinsky I, Ahmed FS, Klinge PM, Relkin NR, Salloway S, Ravdin LD, Brenner E, Malloy PF, Levin BE, Broggi M, Gavett R, Maniscalco JS, Katzen H. Two Novel Psychomotor Tasks in Idiopathic Normal Pressure Hydrocephalus. J Int Neuropsychol Soc. 2016 Mar;22(3):341-9. doi: 10.1017/S1355617715001125. Epub 2016 Jan 28. PMID: 26817685.

5: McElroy A, Rashmir A, Manfredi J, Sledge D, Carr E, Stopa E, Klinge P. Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes. Sci Rep. 2019 Jul 10;9(1):9978. doi: 10.1038/s41598-019-46444-w. PMID: 31292490; PMCID: PMC6620297.

6: Durand WM, Anderson M, Baker A, Daniels AH, Rogg JM, Klinge PM. Meningocele Manqué Discovered During Filum Terminale Resection in Occult Tethered Cord Syndrome. World Neurosurg. 2019 Dec;132:148-153. doi: 10.1016/j.wneu.2019.08.016. Epub 2019 Aug 17. PMID: 31430540.

7: Iyengar RJ, Klinge PM, Chen WS, Boxerman JL, Sullivan SR, Taylor HO. Management of Craniosynostosis at an Advanced Age: Controversies, Clinical Findings, and Surgical Treatment. J Craniofac Surg. 2016 Jul;27(5):e435-41. doi: 10.1097/SCS.0000000000002725. PMID: 27380569.

8: Klinge PM. Idiopathic normal pressure hydrocephalus–neurosurgical management of dementia! Med Health R I. 2012 Mar;95(3):86-7. PMID: 22533225.

9: Niermeyer M, Gaudet C, Malloy P, Piryatinsky I, Salloway S, Klinge P, Lee A. Frontal Behavior Syndromes in Idiopathic Normal Pressure Hydrocephalus as a Function of Alzheimer’s Disease Biomarker Status. J Int Neuropsychol Soc. 2020 Oct;26(9):883-893. doi: 10.1017/S1355617720000387. Epub 2020 May 20. PMID: 32430087; PMCID: PMC7554119.

10: Klinge P, Hellström P, Tans J, Wikkelsø C; European iNPH Multicentre Study Group. One-year outcome in the European multicentre study on iNPH. Acta Neurol Scand. 2012 Sep;126(3):145-53. doi: 10.1111/j.1600-0404.2012.01676.x. Epub 2012 May 10. PMID: 22571428.

11: Hellström P, Klinge P, Tans J, Wikkelsø C. The neuropsychology of iNPH: findings and evaluation of tests in the European multicentre study. Clin Neurol Neurosurg. 2012 Feb;114(2):130-4. doi: 10.1016/j.clineuro.2011.09.014. Epub 2011 Oct 22. PMID: 22023722.

12: Poggi J, Chen WS, Taylor HO, Sullivan S, Woo AS, Klinge PM. Revisiting the Resolution of Chiari Malformation in Nonsyndromic Craniosynostosis: A Case of Posterior Cranial Vault Reconstruction in Secondary Pan-Suture Synostosis. World Neurosurg. 2020 Nov;143:158-162. doi: 10.1016/j.wneu.2020.07.138. Epub 2020 Jul 27 PMID: 32730962.

13: Marmarou A, Bergsneider M, Relkin N, Klinge P, Black PM. Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction. Neurosurgery. 2005 Sep;57(3 Suppl):S1-3; discussion ii-v. doi: 10.1227/01.neu.0000168188.25559.0e. PMID: 16160424.

14: Klinge P, Rückert N, Schuhmann M, Dörner L, Brinker T, Samii M. Neuropsychological testing to improve surgical management of patients with chronic hydrocephalus after shunt treatment. Acta Neurochir Suppl. 2002;81:51-3. doi: 10.1007/978-3-7091-6738-0_13. PMID: 12168355.

15: Beland MD, McElroy AW, Brinker T, Gokaslan ZL, Klinge PM. In Vivo Ultrasound Imaging of the Spinal Cord and Subarachnoid Space at the C1-C2 Level in Healthy Adult Subjects. Ultrasound Q. 2020 Dec 8. doi: 10.1097/RUQ.0000000000000542. Epub ahead of print. PMID: 33298792.

Specialties
Congenital Neurosurgery
Pediatric Neurosurgery
Areas of Expertise
Chiari malformation
Tethered cord syndrome (Pediatric and Adult onset)
Hydrocephalus

Pediatrics
Connective tissue disorders
Cognitive function associated with Chiari and Hydrocepahlsu