Variant Database

The Ehlers-Danlos syndromes (EDS) are a group of 13 heritable connective tissue disorders. The genetic variants that cause EDS are many and varied in their nature. 

To better understand and keep track of these variants, an Ehlers-Danlos Syndrome Variant Database was created. This resource gathers information on genetic variants linked to EDS, allowing healthcare professionals and researchers to identify patterns and enhance medical care. 

The Leiden Open Variation Database (LOVD) is an online platform where scientists and healthcare professionals store and share detailed information about genetic variations in human DNA. Researchers, geneticists, and doctors use LOVD to access and contribute data on genetic mutations and variations, helping to link specific DNA changes to various diseases. This shared data aids in diagnosing genetic conditions and developing personalized treatments based on an individual’s genetic makeup. The database includes detailed information about each genetic variant, including its effects on health and related clinical symptoms. 

LOVD is open to contributions from around the world, making it a comprehensive and collaborative tool for advancing genetic research and medicine. By leveraging the shared knowledge within LOVD, the global scientific and medical community can enhance the understanding and treatment of genetic disorders. This database has been a key tool for over three decades, providing easy and open access to vital genetic data. In 2019, Professor Raymond Dalgleish, an expert in human genetics at the University of Leicester, spearheaded an effort to update and improve this database. Recognizing its importance, The Ehlers-Danlos Society awarded a $75,000 grant for the project and has since taken on the responsibility of maintaining and updating the database with new genetic variant information as it becomes available. 

This initiative is of great importance for those involved in EDS research and care. By keeping the database current and functional, The Ehlers-Danlos Society ensures that this resource continues to be a cornerstone for advancing our understanding of all types of EDS and improving outcomes for those affected by these diverse disorders. The EDS LOVD database is updated and remains under the supervision of The Ehlers-Danlos Society. 

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