This Research Roundup includes studies on vascular Ehlers-Danlos syndrome (vEDS), hypermobile Ehlers-Danlos syndrome (hEDS), and hypermobility spectrum disorder (HSD).
Topics include cell models for vEDS, surgical outcomes in hereditary connective tissue disorders, irritable bowel syndrome (IBS), the effects of psychoactive medication use on heart rhythm, and scoliosis outcomes in adolescents with hypermobility.
Research is an ongoing process, and individual studies contribute to a larger body of evidence. If you’re new to reading research, learn how to find and interpret research papers using our web pages about how to find and how to read research.
Generation of induced pluripotent stem cell (JHUi009-A) and isogenic control (JHUi009-A-1) lines from a patient with vascular Ehlers-Danlos syndrome (vEDS) harboring a pathogenic c.2456G > A in COL3A1
Researchers created stem cell lines from a person with vascular EDS (vEDS), including one line carrying a COL3A1 variant and a control line in which the variant was corrected using gene editing.
Stem cells are cells that can develop into many different cell types. This means they may help researchers study how COL3A1 variants affect different tissues and support future research into targeted treatments for vEDS.
Authors: Wu S, DiSilvestre D, Tomaselli G, Boheler K
DOI: 10.1016/j.scr.2026.104023
Efficacy of Vascular Surgical Interventions in Marfan Syndrome and Ehlers-Danlos Syndrome: A Review of Long‑Term Patient Outcomes
A systematic review examined vascular surgical outcomes in Marfan syndrome and vEDS. Researchers found that specialized surgical approaches, such as the David procedure, were associated with positive long-term outcomes and fewer complications than some alternative techniques.
These findings support ongoing research into tailored surgical care, follow-up strategies, and advances in imaging and surgical techniques for hereditary connective tissue disorders.
Authors: Arunvignesh K, Ananthanarayanan V, Joseph A, Kumar M, Saxena A, Amberkar V
DOI: 10.1007/s12663-025-02636-8
Distinct Age Patterns and Elevated Healthcare Utilization in Irritable Bowel Syndrome Patients with Ehlers-Danlos Syndrome: A National Inpatient Database Analysis
A study of U.S. hospital records found that people with a type of EDS and irritable bowel syndrome (IBS) were hospitalized nearly 24 years younger than those with only IBS.
Having both a type of EDS and IBS was linked to longer hospital stays and higher hospitalization costs. Associations were strongest for mixed-type and constipation-predominant IBS.
These findings support further research into integrated approaches to care and management for these conditions.
Authors: Liu L, Vinh T, Fickel A, Luo P, Billstein L, Pan Q, Cheng Y, Wang Y, Zou Y, Yu X, Cangemi D, Huang Y, Lacy B, Sun C
DOI: 10.1007/s44411-026-00689-w
Psychoactive medication use and cardiac electrophysiology in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder: a retrospective analysis
A study found that people with hypermobile EDS (hEDS) had higher rates of psychiatric diagnoses and psychoactive medication use than people with HSD. People with hEDS more commonly used anticonvulsant medications, which can affect heart rhythm.
Most ECG readings were within normal limits. However, people with HSD had a longer interval for the ventricles to electrically reset between heartbeats, potentially increasing arrhythmia risk. More research is needed to confirm these findings.
Authors: Kaushal R, Snyder I, Tale E, Jarkon L, Riley B, Cohen T
DOI: 10.1515/jom-2025-0053/html
Generalized Joint Hypermobility in Adolescent Idiopathic Scoliosis: Greater Curve Flexibility, Larger Thoracic Kyphosis, but Higher Complication Risk
A study of adolescents with idiopathic scoliosis found that those with generalized joint hypermobility (GJH) had greater spinal flexibility and increased thoracic kyphosis than those without GJH. Adolescents with GJH also had a higher risk of surgical complications.
These findings suggest GJH may be associated with structural spinal changes and support further research into links between hypermobility and scoliosis.
Authors: Liu D, Xu K, Yin X, Zhang T, Wu N
DOI: 10.1111/os.70361
