Low-dose naltrexone (LDN) has been used to treat chronic pain. There is, however, no agreement on effective dosage, leaving clinicians without guidelines on initiating treatment with naltrexone.
A recent research study focused on understanding effective dosing for LDN through an observational study. It was found that the effective dose is highly individual, varying widely among individuals with chronic musculoskeletal pain.
The study suggests that clinicians should consider dosage titration (adjusting the dose) to establish the most effective dose for each patient, as the optimal dose can vary significantly, from 0.1 to 6.0 mg/day, indicating a personalized approach to treatment might be necessary.
For more details, you can access the full paper here. The Ehlers-Danlos Society has funded its open access.
Effective Doses of Low-Dose Naltrexone for Chronic Pain – An Observational Study
